Cytokine profiles and the dynamic of gingivitis development in humans.
J Clin Periodontol
; 49(1): 67-75, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34664296
ABSTRACT
AIM:
To investigate the relationship between cytokine profiles and "fast" and "slow" patterns of gingival inflammation development. MATERIALS ANDMETHODS:
Forty-two adults participated in an experimental gingivitis study, comprising a 2-week hygiene phase (clinical examination and professional cleaning); a 3-week induction phase (absence of oral hygiene); and a 2-week resolution phase (re-establishment of oral hygiene). Plaque and gingival inflammation scores were assessed. Interferon-gamma (IFN-γ), interleukin (IL)-1ß, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, and tumour necrosis factor-alpha (TNF-α) from gingival crevicular fluid were collected and measured by multiplex ELISA. Group-based-trajectory-modelling (GBTM) was used to model cytokine profiles over the induction phase. The effect of gingival inflammation on cytokine levels over time was estimated with mixed-effects modelling.RESULTS:
GBTM analysis revealed two cytokine profiles, "non-organized response" (IL-4, IL-6, IL-8, IL-12, and IL-13) and "organized response" (IL-2, IL-10, and TNF-α). Among the "slow" responders, neither cytokine profile was associated with gingivitis. In contrast, a "fast" response was associated with a higher "non-organized response" factor (coef. 0.14) and a lower "organized response" factor (coef. -0.03).CONCLUSION:
A "fast" gingivitis development was associated with a higher "non-organized response" and a lower "organized response", which may elucidate the role of individual variability in gingivitis susceptibility.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dental Plaque
/
Gingivitis
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
Language:
En
Journal:
J Clin Periodontol
Year:
2022
Document type:
Article
Affiliation country:
Denmark