Skin Autofluorescence as a Novel and Noninvasive Technology for Advanced Glycation End Products in Diabetic Foot Ulcers: A Systematic Review and Meta-analysis.
Adv Skin Wound Care
; 34(11): 1-8, 2021 Nov 01.
Article
in En
| MEDLINE
| ID: mdl-34669666
ABSTRACT
OBJECTIVE:
Skin autofluorescence (SAF) has been suggested as a novel and noninvasive technique for assessing tissue accumulation of advanced glycation end products in diabetes and related complications. The aim of this systematic review and meta-analysis was to evaluate the use of SAF in diabetic foot ulcers (DFUs). DATA SOURCES PubMed/MEDLINE and other digital databases. STUDY SELECTION The authors included studies comparing the SAF levels in patients with DFU with a non-DFU group to determine its association with DFU risk. DATA EXTRACTION Collected data included the SAF method and its values in DFU and non-DFU groups, covariates used in adjustment along with the unadjusted and/or multivariate adjusted odds ratios (ORs) for the association of SAF with DFU risk, and other study characteristics. DATASYNTHESIS:
A total of six studies were included in this meta-analysis. Five studies that involved 611 participants were included to compare SAF methods. Compared with the non-DFU group, the DFU group showed a significantly increased level of SAF (standardized mean difference, 0.67; 95% confidence interval [CI], 0.32-1.01; P < .001). The results of meta-analysis of ORs revealed that the increased SAF level was independently associated with increased DFU risk in both unadjusted (OR, 3.16; 95% CI, 2.18-4.57; P < .001) and adjusted models (OR, 3.07; 95% CI, 1.95-4.81; P < .001).CONCLUSIONS:
These findings suggest that SAF could be useful as a novel and noninvasive technology to help determine DFU risk. However, further studies establishing its diagnostic and prognostic utilities are needed.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin
/
Glycation End Products, Advanced
/
Diabetic Foot
/
Optical Imaging
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Aged
/
Humans
/
Middle aged
Language:
En
Journal:
Adv Skin Wound Care
Journal subject:
ENFERMAGEM
Year:
2021
Document type:
Article