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Physical Activity, Incidence, and Progression of Age-Related Macular Degeneration: A Multicohort Study.
Mauschitz, Matthias M; Schmitz, Marie-Therese; Verzijden, Timo; Schmid, Matthias; Thee, Eric F; Colijn, Johanna M; Delcourt, Cécile; Cougnard-Grégoire, Audrey; Merle, Bénédicte M J; Korobelnik, Jean-François; Gopinath, Bamini; Mitchell, Paul; Elbaz, Hisham; Schuster, Alexander K; Wild, Philipp S; Brandl, Caroline; Stark, Klaus J; Heid, Iris M; Günther, Felix; Peters, Annette; Klaver, Caroline C W; Finger, Robert P.
Affiliation
  • Mauschitz MM; Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany. Electronic address: Matthias.Mauschitz@ukbonn.de.
  • Schmitz MT; Department of Medical Biometry, Informatics and Epidemiology (M.-T.S., M.S.), Medical Faculty, University of Bonn, Bonn, Germany.
  • Verzijden T; Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
  • Schmid M; Department of Medical Biometry, Informatics and Epidemiology (M.-T.S., M.S.), Medical Faculty, University of Bonn, Bonn, Germany.
  • Thee EF; Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
  • Colijn JM; Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands.
  • Delcourt C; Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
  • Cougnard-Grégoire A; Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
  • Merle BMJ; Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
  • Korobelnik JF; Bordeaux Population Health Research Center (C.D., A.C.-G., B.M.J.M., J.-F.K.), University of Bordeaux, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1219, Team Lifelong Exposures Health and Aging (LEHA), Bordeaux, France.
  • Gopinath B; Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia; Department of Linguistics (B.G.,), Macquarie University Hearing, Macquarie University, Sydney, New South Wales, Australia.
  • Mitchell P; Centre for Vision Research, Department of Ophthalmology (B.G., P.M.), The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
  • Elbaz H; Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany; Department of Ophthalmology (H.E.), Otto-von-Guericke University, Magdeburg, Germany.
  • Schuster AK; Department of Ophthalmology (H.E., A.K.S.), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
  • Wild PS; Preventive Cardiology and Preventive Medicine, Center for Cardiology (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; Center for Thrombosis and Hemostasis (P.S.W.), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany; DZ
  • Brandl C; Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Department of Ophthalmology (C.B.), University Hospital Regensburg, Regensburg, Germany.
  • Stark KJ; Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany.
  • Heid IM; Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany.
  • Günther F; Department of Genetic Epidemiology (C.B., K.J.S., I.M.H., F.G.), University Hospital Regensburg, Regensburg, Germany; Statistical Consulting Unit StaBLab, Department of Statistics (F.G.), Ludwig-Maximilians-University Munich, Germany.
  • Peters A; Institute of Epidemiology (A.P.), Helmholtz Center Munich, Germany; Department of Epidemiology, Institute for Medical Information Processing, Biometry and Epidemiology (A.P.), Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Klaver CCW; Department of Ophthalmology (T.V., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Epidemiology (T.V., M.S., E.F.T., J.M.C., C.C.W.K.), Erasmus MC, Rotterdam, the Netherlands; Department of Opthalmology (C.C.W.K.), Radboudumc, Nijmegen, the Netherlands; Institute of
  • Finger RP; Department of Ophthalmology (M.M.M., R.P.F.), University Hospital Bonn, Bonn, Germany.
Am J Ophthalmol ; 236: 99-106, 2022 04.
Article in En | MEDLINE | ID: mdl-34695401
ABSTRACT

PURPOSE:

To investigate the impact of physical activity (PA) on the incidence or progression of age-related macular degeneration (AMD) in the general population.

DESIGN:

Meta-analysis of longitudinal cohort studies.

METHODS:

We included 14,630 adults with no or early AMD at baseline from 7 population-based studies and examined associations of PA with AMD incidence and progression using multistate models (MSM) per study and subsequent random effects meta-analysis. Age effects were assessed using meta-regression. The main outcome measure was the hazard ratio (HR) for incident early or progression to late AMD.

RESULTS:

At baseline, mean age was 60.7 ± 6.9 to 76.4 ± 4.3 years, and prevalence of early AMD was 7.7% (range, 3.6%-16.9%) between cohorts. During follow-up, 1461 and 189 events occurred for early and late AMD, respectively. In meta-analyses, no or low to moderate PA (high PA as reference) was associated with an increased risk for incident early AMD (HR, 1.19; 95% CI, 1.01-1.40; P = .04), but not for late AMD. In subsequent meta-regression, we found no association of age with the effect of PA on incident AMD.

CONCLUSIONS:

Our study suggests high levels of PA to be protective for the development of early AMD across several population-based cohort studies. Our results establish PA as a modifiable risk factor for AMD and inform further AMD prevention strategies to reduce its public health impact.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macular Degeneration Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Am J Ophthalmol Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Macular Degeneration Type of study: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Adult / Aged / Humans / Middle aged Language: En Journal: Am J Ophthalmol Year: 2022 Document type: Article