Malignancy: An Adverse Effect of Immunosuppression.
Handb Exp Pharmacol
; 272: 315-335, 2022.
Article
in En
| MEDLINE
| ID: mdl-34697663
ABSTRACT
Benefits of solid organ transplantation in end stage organ diseases are indisputable. Malignancy is a feared complication of solid organ transplantation and is a leading cause of mortality in patients with organ transplantation. Iatrogenic immunosuppression to prevent graft rejection plays a crucial role in the cancer development in solid organ transplant recipients. Chronic exposure to immunosuppression increases the malignancy burden through deregulation of host immune defense mechanisms and unchecked proliferation of oncogenic viruses and malignancies associated with these viruses. Vigorous screening of candidates undergoing transplant evaluation for malignancies, careful assessment of donors, and vigilant monitoring of transplant recipients are necessary to prevent, detect, and manage this life-threatening complication.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Organ Transplantation
/
Drug-Related Side Effects and Adverse Reactions
/
Neoplasms
Limits:
Humans
Language:
En
Journal:
Handb Exp Pharmacol
Year:
2022
Document type:
Article
Affiliation country:
United States