Heme-dependent recognition of 5-aminolevulinate synthase by the human mitochondrial molecular chaperone ClpX.

Nomura, Kazumi; Kitagawa, Yu; Aihara, Marina; Ohki, Yusuke; Furuyama, Kazumichi; Hirokawa, Takatsugu

Nomura, Kazumi; Kitagawa, Yu; Aihara, Marina; Ohki, Yusuke; Furuyama, Kazumichi; Hirokawa, Takatsugu.

Affiliation

Nomura K; Department of Molecular Biochemistry, Iwate Medical University, Japan.
Kitagawa Y; Department of Molecular Biochemistry, Iwate Medical University, Japan.
Aihara M; Department of Molecular Biochemistry, Iwate Medical University, Japan.
Ohki Y; Department of Molecular Biochemistry, Iwate Medical University, Japan.
Furuyama K; Department of Molecular Biochemistry, Iwate Medical University, Japan.
Hirokawa T; Division of Biomedical Science, Faculty of Medicine, University of Tsukuba, Japan.

FEBS Lett ; 595(24): 3019-3029, 2021 12.

Article in En | MEDLINE | ID: mdl-34704252

Subject(s)

5-Aminolevulinate Synthetase/metabolism; Endopeptidase Clp/metabolism; Heme/metabolism; Mitochondria/metabolism; Molecular Chaperones/metabolism; 5-Aminolevulinate Synthetase/chemistry; Adenosine Diphosphate/metabolism; Adenosine Triphosphate/metabolism; Amino Acid Motifs; Amino Acid Sequence; Hemin/metabolism; Humans; Intrinsically Disordered Proteins/metabolism; Models, Biological; Protein Binding

Key words

ALAS1; ClpX; ClpXP proteolytic machinery; heme-regulated proteins; intrinsically disordered protein regions; molecular chaperone

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Molecular Chaperones / Endopeptidase Clp / 5-Aminolevulinate Synthetase / Heme / Mitochondria Limits: Humans Language: En Journal: FEBS Lett Year: 2021 Document type: Article Affiliation country: Japan

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