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Facile synthesis of near-infrared bodipy by donor engineering for in vivo tumor targeted dual-modal imaging.
An, Feifei; Xin, Jingqi; Deng, Caiting; Tan, Xiaofang; Aras, Omer; Chen, Nandi; Zhang, Xiaohong; Ting, Richard.
Affiliation
  • An F; Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, People's Republic of China.
  • Xin J; Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medical College, 413 East 69th Street, New York, NY 10065, USA. rct2001@med.cornell.edu.
  • Deng C; Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, People's Republic of China.
  • Tan X; Institute of Medical Engineering, Department of Biophysics, School of Basic Medical Science, Health Science Center, Xi'an Jiaotong University, No. 76 Yanta West Road, Xi'an 710061, Shaanxi, People's Republic of China.
  • Aras O; Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China. xiaohong_zhang@suda.edu.cn.
  • Chen N; Jiangsu Institute of Marine Resources Development, Jiangsu Ocean University, 59 Cangwu Road, Lianyungang 222005, Jiangsu, People's Republic of China.
  • Zhang X; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
  • Ting R; Molecular Imaging Innovations Institute (MI3), Department of Radiology, Weill Cornell Medical College, 413 East 69th Street, New York, NY 10065, USA. rct2001@med.cornell.edu.
J Mater Chem B ; 9(45): 9308-9315, 2021 11 24.
Article in En | MEDLINE | ID: mdl-34714318
ABSTRACT
Bodipy is one of the most popular dyes for bioimaging, however, a complicated synthetic protocol is needed to create and isolate ideal near-infrared (NIR) emissive Bodipy derivatives for optical bioimaging. It is noticed that the donor species impact the wavelength when the π-conjugation system of green light emissive Bodipy is elongated via a one-step reaction. Herein, several Bodipy dyes bearing different common donors are synthesized. Their optical properties confirm that both absorption and emission peaks of the synthesized Bodipy could be tuned to NIR wavelength by using stronger donors via a facile reaction. The synthesized monocarboxyl Bodipy could conjugate with aminated PEG to yield an amphiphilic polymer, which further self-assembles into a NIR nanoparticle (NP). The NIR NP exhibits preferential tumor accumulation via the enhanced permeation and retention (EPR) effect, making it useful for tumor diagnosis by both fluorescence imaging and photoacoustic tomography.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron Compounds / Chemical Engineering / Adenocarcinoma of Lung / Neoplasms Type of study: Guideline Limits: Animals / Humans Language: En Journal: J Mater Chem B Year: 2021 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boron Compounds / Chemical Engineering / Adenocarcinoma of Lung / Neoplasms Type of study: Guideline Limits: Animals / Humans Language: En Journal: J Mater Chem B Year: 2021 Document type: Article