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Single-cell analysis of arthritogenic alphavirus-infected human synovial fibroblasts links low abundance of viral RNA to induction of innate immunity and arthralgia-associated gene expression.
Pott, Fabian; Postmus, Dylan; Brown, Richard J P; Wyler, Emanuel; Neumann, Elena; Landthaler, Markus; Goffinet, Christine.
Affiliation
  • Pott F; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Postmus D; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.
  • Brown RJP; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
  • Wyler E; Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Berlin, Germany.
  • Neumann E; Division of Veterinary Medicine, Paul Ehrlich Institute, Langen, Germany.
  • Landthaler M; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Berlin, Germany.
  • Goffinet C; Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Bad Nauheim, Germany.
Emerg Microbes Infect ; 10(1): 2151-2168, 2021 Dec.
Article in En | MEDLINE | ID: mdl-34723780
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arbovirus Infections / Arboviruses / Synovial Fluid / RNA, Viral / Arthralgia / Immunity, Innate Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2021 Document type: Article Affiliation country: Germany
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arbovirus Infections / Arboviruses / Synovial Fluid / RNA, Viral / Arthralgia / Immunity, Innate Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2021 Document type: Article Affiliation country: Germany