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Lead optimization of novel quinolone chalcone compounds by a structure-activity relationship (SAR) study to increase efficacy and metabolic stability.
Knockleby, James; Djigo, Aïcha Dede; Lindamulage, Indeewari Kalhari; Karthikeyan, Chandrabose; Trivedi, Piyush; Lee, Hoyun.
Affiliation
  • Knockleby J; Health Science North Research Institute, 56 Walford Road, Sudbury, ON, P3E 2H3, Canada.
  • Djigo AD; Department of Chemistry and Biochemistry, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.
  • Lindamulage IK; Health Science North Research Institute, 56 Walford Road, Sudbury, ON, P3E 2H3, Canada.
  • Karthikeyan C; Health Science North Research Institute, 56 Walford Road, Sudbury, ON, P3E 2H3, Canada.
  • Trivedi P; Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, 484887, India.
  • Lee H; Center of Innovation and Translational Research, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune, 411 038, India.
Sci Rep ; 11(1): 21576, 2021 11 03.
Article in En | MEDLINE | ID: mdl-34732782
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Structure-Activity Relationship / Drug Design / Quinolones / Chalcones Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Canada Country of publication: United kingdom
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Structure-Activity Relationship / Drug Design / Quinolones / Chalcones Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: Canada Country of publication: United kingdom