Research progress in immune microenvironment regulation of muscle atrophy induced by peripheral nerve injury.
Life Sci
; 287: 120117, 2021 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-34740577
ABSTRACT
Denervated skeletal muscular atrophy is primarily characterized by loss of muscle strength and mass and an unideal functional recovery of the muscle after extended denervation. This review emphasizes the interaction between the immune system and the denervated skeletal muscle. Immune cells such as neutrophils, macrophages and T-cells are activated and migrate to denervated muscle, where they release a high concentration of cytokines and chemokines. The migration of these immune cells, the transformation of different functional immune cell subtypes, and the cytokine network in the immune microenvironment may be involved in the regulatory process of muscle atrophy or repair. However, the exact mechanisms of the interaction between these immune cells and immune molecules in skeletal muscles are unclear. In this paper, the immune microenvironment regulation of muscle atrophy induced by peripheral nerve injury is reviewed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Muscular Atrophy
/
Muscle, Skeletal
/
Biomedical Research
/
Peripheral Nerve Injuries
/
Cellular Microenvironment
/
Immunity, Cellular
Limits:
Animals
/
Humans
Language:
En
Journal:
Life Sci
Year:
2021
Document type:
Article
Affiliation country:
China