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GLI1-targeting drugs induce replication stress and homologous recombination deficiency and synergize with PARP-targeted therapies in triple negative breast cancer cells.
Mani, Chinnadurai; Tripathi, Kaushlendra; Omy, Tasmin R; Reedy, Mark; Manne, Upender; Palle, Komaraiah.
Affiliation
  • Mani C; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: chinnadurai.mani@ttuhsc.edu.
  • Tripathi K; Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36904, USA.
  • Omy TR; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
  • Reedy M; Department of Obstetrics and Gynecology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
  • Manne U; Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Palle K; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. Electronic address: komaraiah.palle@ttuhsc.edu.
Biochim Biophys Acta Mol Basis Dis ; 1868(2): 166300, 2022 02 01.
Article in En | MEDLINE | ID: mdl-34748904
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / DNA Replication / Drug Synergism / Homologous Recombination / Triple Negative Breast Neoplasms / Poly(ADP-ribose) Polymerase Inhibitors / Zinc Finger Protein GLI1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2022 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Pyrimidines / DNA Replication / Drug Synergism / Homologous Recombination / Triple Negative Breast Neoplasms / Poly(ADP-ribose) Polymerase Inhibitors / Zinc Finger Protein GLI1 Type of study: Prognostic_studies Limits: Humans Language: En Journal: Biochim Biophys Acta Mol Basis Dis Year: 2022 Document type: Article