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Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease.
Hogarth, Marshall W; Uapinyoying, Prech; Mázala, Davi A G; Jaiswal, Jyoti K.
Affiliation
  • Hogarth MW; Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA. Electronic address: mhogarth@cnmc.org.
  • Uapinyoying P; Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Neuromuscular and Neurogenetic Disorders of Childhood Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA.
  • Mázala DAG; Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Department of Kinesiology, College of Health Professions, Towson University, Maryland, USA.
  • Jaiswal JK; Children's National Hospital, Center for Genetic Medicine Research, Washington, DC, USA; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA. Electronic address: jkjaiswal@cnmc.org.
Trends Mol Med ; 28(1): 8-11, 2022 01.
Article in En | MEDLINE | ID: mdl-34750068
ABSTRACT
Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipogenesis / Mesenchymal Stem Cells Limits: Adult / Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adipogenesis / Mesenchymal Stem Cells Limits: Adult / Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article