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Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Lyczek, Agatha; Berger, Benedict-Tilman; Rangwala, Aziz M; Paung, YiTing; Tom, Jessica; Philipose, Hannah; Guo, Jiaye; Albanese, Steven K; Robers, Matthew B; Knapp, Stefan; Chodera, John D; Seeliger, Markus A.
Affiliation
  • Lyczek A; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794.
  • Berger BT; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main 60438, Germany.
  • Rangwala AM; Structural Genomics Consortium, Buchmann Institute for Life Sciences, Goethe University Frankfurt, Frankfurt am Main 60438, Germany.
  • Paung Y; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794.
  • Tom J; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794.
  • Philipose H; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794.
  • Guo J; Department of Pharmacological Sciences, Stony Brook University School of Medicine, Stony Brook, NY 11794.
  • Albanese SK; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Robers MB; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Knapp S; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
  • Chodera JD; Research and Development Department, Promega Corporation, Fitchburg, WI 53711.
  • Seeliger MA; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt am Main 60438, Germany.
Proc Natl Acad Sci U S A ; 118(46)2021 11 16.
Article in En | MEDLINE | ID: mdl-34750265
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fusion Proteins, bcr-abl / Drug Resistance, Neoplasm / Imatinib Mesylate / Mutation Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fusion Proteins, bcr-abl / Drug Resistance, Neoplasm / Imatinib Mesylate / Mutation Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2021 Document type: Article Country of publication: United States