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Advances in the treatment, diagnosis, control and scientific understanding of taeniid cestode parasite infections over the past 50 years.
Lightowlers, Marshall W; Gasser, Robin B; Hemphill, Andrew; Romig, Thomas; Tamarozzi, Francesca; Deplazes, Peter; Torgerson, Paul R; Garcia, Hector H; Kern, Peter.
Affiliation
  • Lightowlers MW; Department of Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia. Electronic address: marshall@unimelb.edu.au.
  • Gasser RB; Department of Biosciences, Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, Victoria 3010, Australia.
  • Hemphill A; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Länggassstrasse 122, 3012 Bern, Switzerland.
  • Romig T; University of Hohenheim, Parasitology Unit, Emil-Wolff-Strasse 34, 70599 Stuttgart, Germany.
  • Tamarozzi F; Department of Infectious Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella, Verona, Italy.
  • Deplazes P; Institute of Parasitology, Vetsuisse, and Medical Faculty, University of Zürich, Zürich, Switzerland.
  • Torgerson PR; Section of Epidemiology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.
  • Garcia HH; Infectious Diseases Laboratory Research-LID, Faculty of Science and Philosophy, Alberto Cazorla Talleri, Universidad Peruana Cayetano Heredia, Lima, Perú; Cysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Perú.
  • Kern P; Ulm University Hospital, Division of Infectious Diseases, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Int J Parasitol ; 51(13-14): 1167-1192, 2021 12.
Article in En | MEDLINE | ID: mdl-34757089
In the past 50 years, enormous progress has been made in the diagnosis, treatment and control of taeniid cestode infections/diseases and in the scientific understanding thereof. Most interest in this group of parasites stems from the serious diseases that they cause in humans. It is through this lens that we summarize here the most important breakthroughs that have made a difference to the treatment of human diseases caused by these parasites, reduction in transmission of the taeniid species associated with human disease, or understanding of the parasites' biology likely to impact diagnosis or treatment in the foreseeable future. Key topics discussed are the introduction of anti-cestode drugs, including benzimidazoles and praziquantel, and the development of new imaging modalities that have transformed the diagnosis and post-treatment monitoring of human echinococcoses and neurocysticercosis. The availability of new anti-cestode drugs for use in dogs and a detailed understanding of the transmission dynamics of Echinococcus granulosus sensu lato have underpinned successful programs that have eliminated cystic echinococcosis in some areas of the world and greatly reduced the incidence of infection in others. Despite these successes, cystic and alveolar echinococcosis and neurocysticercosis continue to be prevalent in many parts of the world, requiring new or renewed efforts to prevent the associated taeniid infections. Major advances made in the development of practical vaccines against E. granulosus and Taenia solium will hopefully assist in this endeavour, as might the understanding of the parasites' biology that have come from an elucidation of the nuclear genomes of each of the most important taeniid species causing human diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasites / Cestoda / Cestode Infections / Neurocysticercosis / Echinococcus granulosus / Echinococcosis Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Int J Parasitol Year: 2021 Document type: Article Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parasites / Cestoda / Cestode Infections / Neurocysticercosis / Echinococcus granulosus / Echinococcosis Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Int J Parasitol Year: 2021 Document type: Article Country of publication: United kingdom