Bioprinting of Cartilage with Bioink Based on High-Concentration Collagen and Chondrocytes.
Int J Mol Sci
; 22(21)2021 Oct 21.
Article
in En
| MEDLINE
| ID: mdl-34768781
ABSTRACT
The study was aimed at the applicability of a bioink based on 4% collagen and chondrocytes for de novo cartilage formation. Extrusion-based bioprinting was used for the biofabrication. The printing parameters were tuned to obtain stable material flow. In vivo data proved the ability of the tested bioink to form a cartilage within five to six weeks after the subcutaneous scaffold implantation. Certain areas of cartilage formation were detected as early as in one week. The resulting cartilage tissue had a distinctive structure with groups of isogenic cells as well as a high content of glycosaminoglycans and type II collagen.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cartilage
/
Tissue Engineering
/
Bioprinting
Limits:
Animals
Language:
En
Journal:
Int J Mol Sci
Year:
2021
Document type:
Article
Affiliation country:
RUSSIA