Cromolyn platform suppresses fibrosis and inflammation, promotes microglial phagocytosis and neurite outgrowth.

Wang, Yi-Jun; Downey, Matthew A; Choi, Sungwoon; Shoup, Timothy M; Elmaleh, David R

Wang, Yi-Jun; Downey, Matthew A; Choi, Sungwoon; Shoup, Timothy M; Elmaleh, David R.

Affiliation

Wang YJ; AZTherapies, Inc., Boston, MA, USA.
Downey MA; AZTherapies, Inc., Boston, MA, USA.
Choi S; Department of New Drug Discovery, Chungnam National University, Daejeon, South Korea.
Shoup TM; Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129-2060, USA.
Elmaleh DR; AZTherapies, Inc., Boston, MA, USA. delmaleh@mgh.harvard.edu.

Sci Rep ; 11(1): 22161, 2021 11 12.

Article in En | MEDLINE | ID: mdl-34772945

Subject(s)

Cromolyn Sodium/pharmacology; Microglia/immunology; Microglia/metabolism; Neuroinflammatory Diseases/etiology; Neuroinflammatory Diseases/metabolism; Neuronal Outgrowth/drug effects; Phagocytosis/drug effects; Phagocytosis/immunology; Amyloid beta-Peptides/metabolism; Animals; Biomarkers; Cell Line; Computational Biology/methods; Cytokines/metabolism; Disease Susceptibility; Fibrosis; Gene Expression Profiling; Gene Expression Regulation/drug effects; Gene Regulatory Networks; Humans; Microglia/pathology; Neuroinflammatory Diseases/drug therapy; Neuroinflammatory Diseases/pathology; Peptide Fragments/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Proteome; Signal Transduction/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Cromolyn Sodium / Microglia / Neuronal Outgrowth / Neuroinflammatory Diseases Limits: Animals / Humans Language: En Journal: Sci Rep Year: 2021 Document type: Article Affiliation country: United States Country of publication: United kingdom

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