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The use of high-dose immunoglobulin M-enriched human immunoglobulin in dogs with immune-mediated hemolytic anemia.
Bestwick, Jason P; Sharman, Mellora; Whitley, Nat T; Kisielewicz, Caroline; Skelly, Barbara J; Tappin, Simon; Kellett-Gregory, Lindsay; Seth, Mayank.
Affiliation
  • Bestwick JP; Animal Health Trust, Suffolk, United Kingdom.
  • Sharman M; Animal Health Trust, Suffolk, United Kingdom.
  • Whitley NT; Davies Veterinary Specialists, Hertfordshire, United Kingdom.
  • Kisielewicz C; Pride Veterinary Centre, Derby, United Kingdom.
  • Skelly BJ; Queen's Veterinary School, Cambridge, United Kingdom.
  • Tappin S; Dick White Referrals, Station Farm, Cambridgeshire, United Kingdom.
  • Kellett-Gregory L; Queen Mother Hospital for Animals, The Royal Veterinary College, Hertfordshire, United Kingdom.
  • Seth M; Animal Health Trust, Suffolk, United Kingdom.
J Vet Intern Med ; 36(1): 78-85, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34779044
ABSTRACT

BACKGROUND:

The IV use of human immunoglobulin (hIVIG) in dogs with primary immune-mediated hemolytic anemia (IMHA) has been described previously, but herein we describe the use of high-dose IgM-enriched hIVIG (Pentaglobin). HYPOTHESIS/

OBJECTIVES:

Dogs treated with high-dose Pentaglobin will experience shorter time to remission and hospital discharge and have decreased transfusion requirements compared to dogs receiving standard treatment alone. ANIMALS Fourteen client-owned dogs diagnosed with primary IMHA at specialist referral hospitals in the United Kingdom.

METHODS:

All prospectively enrolled dogs received prednisolone, dexamethasone or both along with clopidogrel. Patients were randomized to receive Pentaglobin at 1 g/kg on up to 2 occasions, or to serve as controls. No additional immunosuppressive drugs were allowed within the first 7 days of treatment. Remission was defined as stable PCV for 24 hours followed by an increase in PCV.

RESULTS:

Ten of 11 dogs from the treatment group and 2 of 3 dogs from the control group achieved remission and survived until hospital discharge. Survival and time to remission were not significantly different between groups. The volume of packed red blood cells transfused, normalized for body weight, was not significantly different between groups. Potential adverse reactions to Pentaglobin occurred in 2 dogs, but their clinical signs may have been related to the underlying disease. CONCLUSIONS AND CLINICAL IMPORTANCE Treatment with high-dose Pentaglobin was well tolerated by dogs with primary IMHA but no significant advantage was found in this small study. Additional studies examining larger groups and subpopulations of dogs with primary IMHA associated with a poorer prognosis are warranted.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dog Diseases / Anemia, Hemolytic, Autoimmune Type of study: Clinical_trials Limits: Animals / Humans Language: En Journal: J Vet Intern Med Journal subject: MEDICINA INTERNA / MEDICINA VETERINARIA Year: 2022 Document type: Article Affiliation country: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dog Diseases / Anemia, Hemolytic, Autoimmune Type of study: Clinical_trials Limits: Animals / Humans Language: En Journal: J Vet Intern Med Journal subject: MEDICINA INTERNA / MEDICINA VETERINARIA Year: 2022 Document type: Article Affiliation country: United kingdom