Sensitive identification of neoantigens and cognate TCRs in human solid tumors.
Nat Biotechnol
; 40(5): 656-660, 2022 05.
Article
in En
| MEDLINE
| ID: mdl-34782741
ABSTRACT
The identification of patient-specific tumor antigens is complicated by the low frequency of T cells specific for each tumor antigen. Here we describe NeoScreen, a method that enables the sensitive identification of rare tumor (neo)antigens and of cognate T cell receptors (TCRs) expressed by tumor-infiltrating lymphocytes. T cells transduced with tumor antigen-specific TCRs identified by NeoScreen mediate regression of established tumors in patient-derived xenograft mice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Antigen, T-Cell
/
Neoplasms
Type of study:
Diagnostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Biotechnol
Journal subject:
BIOTECNOLOGIA
Year:
2022
Document type:
Article
Affiliation country:
Switzerland