Relative Source Power: A novel method for localizing epileptiform EEG discharges.
Clin Neurophysiol
; 133: 9-19, 2022 01.
Article
in En
| MEDLINE
| ID: mdl-34788717
ABSTRACT
OBJECTIVE:
To validate relative source power (RSP) imaging of extratemporal interictal epileptiform discharges (IEDs).METHODS:
The accuracy of RSP was validated in a cohort of patients with extratemporal focal epilepsy and a confined epileptogenic lesion (<19 cm3) using distance to the lesion, concordance with resected area and postoperative outcome. Performance was compared with three conventionalmethods:
voltage maps, equivalent current dipole and a distributed source model.RESULTS:
Thirty-three of 41 consecutive patients (80%) had IED averages suitable for analysis. While the peak negativity in voltage maps localized above the epileptogenic lesion only in 18 cases, RSP-maps matched in 29 cases (88%, p < 0.0026). Source localization showed a median distance of 9.8 mm from the lesion. Source-regions with 20 mm radius included 98% of all source-to-lesion distances. In the 21 surgical cases, outcome showed a sensitivity of 82.35% and specificity of 50% without significant differences between the three source imaging methods.CONCLUSIONS:
RSP-maps provide a rapid, intuitive and more accurate source estimation than voltage maps. At sublobar level, RSP localizes with an accuracy similar to conventional methods and results of previous studies.SIGNIFICANCE:
The definition of a source region with 20 mm radius helps in guiding further exploration in extratemporal focal epilepsy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Epilepsy
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Neurophysiol
Journal subject:
NEUROLOGIA
/
PSICOFISIOLOGIA
Year:
2022
Document type:
Article