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Surface-Catalyzed Secondary Nucleation Dominates the Generation of Toxic IAPP Aggregates.
Rodriguez Camargo, Diana C; Chia, Sean; Menzies, Joseph; Mannini, Benedetta; Meisl, Georg; Lundqvist, Martin; Pohl, Christin; Bernfur, Katja; Lattanzi, Veronica; Habchi, Johnny; Cohen, Samuel Ia; Knowles, Tuomas P J; Vendruscolo, Michele; Linse, Sara.
Affiliation
  • Rodriguez Camargo DC; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
  • Chia S; Wren Therapeutics Limited, Clarendon House, Cambridge, United Kingdom.
  • Menzies J; Wren Therapeutics Limited, Clarendon House, Cambridge, United Kingdom.
  • Mannini B; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
  • Meisl G; Wren Therapeutics Limited, Clarendon House, Cambridge, United Kingdom.
  • Lundqvist M; Wren Therapeutics Limited, Clarendon House, Cambridge, United Kingdom.
  • Pohl C; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
  • Bernfur K; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
  • Lattanzi V; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
  • Habchi J; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
  • Cohen SI; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
  • Knowles TPJ; Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.
  • Vendruscolo M; Wren Therapeutics Limited, Clarendon House, Cambridge, United Kingdom.
  • Linse S; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Front Mol Biosci ; 8: 757425, 2021.
Article in En | MEDLINE | ID: mdl-34790701
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Mol Biosci Year: 2021 Document type: Article Affiliation country: Sweden Country of publication: Switzerland
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Mol Biosci Year: 2021 Document type: Article Affiliation country: Sweden Country of publication: Switzerland