Insights from modelling malaria vaccines for policy decisions: the focus on RTS,S.
Malar J
; 20(1): 439, 2021 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-34794430
ABSTRACT
Mathematical models are increasingly used to inform decisions throughout product development pathways from pre-clinical studies to country implementation of novel health interventions. This review illustrates the utility of simulation approaches by reviewing the literature on malaria vaccine modelling, with a focus on its link to the development of policy guidance for the first licensed product, RTS,S/AS01. The main contributions of modelling studies have been in inferring the mechanism of action and efficacy profile of RTS,S; to predicting the public health impact; and economic modelling mainly comprising cost-effectiveness analysis. The value of both product-specific and generic modelling of vaccines is highlighted.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Malaria Vaccines
Type of study:
Guideline
/
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Malar J
Journal subject:
MEDICINA TROPICAL
Year:
2021
Document type:
Article
Affiliation country:
Switzerland