Prevention, treatment, and risk factors of deep vein thrombosis in critically ill patients in Zhejiang province, China: a multicenter, prospective, observational study.
Ann Med
; 53(1): 2234-2245, 2021 12.
Article
in En
| MEDLINE
| ID: mdl-34797177
ABSTRACT
PURPOSE:
The aim of this study is to investigate the prevention and treatment patterns of deep vein thrombosis (DVT) in critically ill patients and to explore the risk factors for DVT in people from Zhejiang Province, China. MATERIALS ANDMETHODS:
This study prospectively enrolled patients admitted in intensive care units (ICUs) of 54 hospitals from 09/16/2019 to 01/16/2020. The risk of developing DVT and subsequent prophylaxis was evaluated. The primary outcome was DVT occurrence during ICU hospitalisation. Univariate and multivariate logistic regression were performed to determine the risk factors for DVT.RESULTS:
A total of 940 patients were included in the study. Among 847 patients who received prophylaxis, 635 (75.0%) patients received physical prophylaxis and 199 (23.5%) patients received drug prophylaxis. Fifty-eight (6.2%) patients were diagnosed with DVT after admission to the ICU, and 36 patients were treated with anticoagulants (all patients received low molecular weight heparin [LMWH]). D-dimer levels (OR = 1.256, 95% CI 1.132-1.990), basic prophylaxis (OR = 0.092, 95% CI 0.016-0.536), and physical prophylaxis (OR = 0.159, 95% CI 0.038-0.674) were independently associated with DVT in ICU patients. The short-term survival was similar between DVT and non-DVT patients.CONCLUSIONS:
DVT prophylaxis is widely performed in ICU patients. Prophylaxis is an independent protective factor for DVT occurrence. The most common treatment of DVT patients is LMWH, although it might increase the rate of bleeding.Key messagesThis is the only multicenter and prospective study of DVT in ICUs in China.d-dimer levels were independently associated with DVT in ICU patients.Prophylaxis was an independent protective factor for DVT occurrence in ICU.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Critical Illness
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Heparin, Low-Molecular-Weight
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Venous Thrombosis
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Intensive Care Units
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Anticoagulants
Type of study:
Clinical_trials
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Etiology_studies
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Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Ann Med
Journal subject:
MEDICINA
Year:
2021
Document type:
Article
Affiliation country:
China