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Spindle Cell Lipoma with Ossification Mimicking Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma: A Case Report.
Ichikawa, Jiro; Kawasaki, Tomonori; Imada, Hiroki; Enomoto, Atsushi; Taniguchi, Naofumi; Tatsuno, Rikito; Kanno, Satoshi; Haro, Hirotaka.
Affiliation
  • Ichikawa J; 38147Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
  • Kawasaki T; 183786Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
  • Imada H; Department of Pathology, Saitama Medical Center, 183786Saitama Medical University, Kawagoeshi, Saitama, Japan.
  • Enomoto A; 12965Department of Pathology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi, Japan.
  • Taniguchi N; 38147Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
  • Tatsuno R; 38147Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
  • Kanno S; 183786Department of Pathology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan.
  • Haro H; 38147Department of Orthopaedic Surgery, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Int J Surg Pathol ; 30(4): 413-418, 2022 Jun.
Article in En | MEDLINE | ID: mdl-34812072
ABSTRACT
Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. In this article, we present a case of SCL with ossification mimicking atypical lipomatous tumors/well-differentiated liposarcomas (ALTs/WDLs). Considering the findings of magnetic resonance imaging and needle biopsy, which exhibited ALTs/WDLs, marginal resection was performed. Histopathological findings demonstrated mature adipocytes and spindle cells without atypia and no malignant osteoid tissue in the ossified region. In addition, immunohistochemistry (IHC) showed positive staining for CD34, heterogeneous retinoblastoma protein deficiency, and negative staining for mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase. Fluorescence in-situ hybridization showed negative amplification of MDM2. The final diagnosis of the tumor was established using IHC as an extremely rare SCL with ossification.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neoplasms / Lipoma / Liposarcoma Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Int J Surg Pathol Journal subject: PATOLOGIA Year: 2022 Document type: Article Affiliation country: Japan
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neoplasms / Lipoma / Liposarcoma Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Int J Surg Pathol Journal subject: PATOLOGIA Year: 2022 Document type: Article Affiliation country: Japan