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Improved water dispersion and bioavailability of coenzyme Q10 by bacterial cellulose nanofibers.
Li, Yuanyuan; Yang, Qilei; Liu, Bingxue; Zhang, Qian; Liu, Yanjie; Zhao, Xiuhua; Li, Shujun.
Affiliation
  • Li Y; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China; Key Laboratory of B
  • Yang Q; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Liu B; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Zhang Q; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Liu Y; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China.
  • Zhao X; College of Chemistry, Chemical Engineering and Resource Utilization, Northeast Forestry University, Harbin, China, Harbin 150040, Heilongjiang, China; Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, Heilongjiang, China. Electronic address:
  • Li S; Key Laboratory of Bio-Based Material Science and Technology of Ministry of Education Northeast Forestry University, Harbin 150040, Heilongjiang, China. Electronic address: lishujun@nefu.edu.cn.
Carbohydr Polym ; 276: 118788, 2022 Jan 15.
Article in En | MEDLINE | ID: mdl-34823798
ABSTRACT
The purpose of this study was to investigate the potential of bacterial cellulose nanofiber suspension (BCNs) as stabilizer in anti-solvent precipitation and its effect on improving bioavailability of coenzyme Q10. Bacterial cellulose (BC) was hydrolyzed by sulfuric acid followed by the oxidation with hydrogen peroxide to prepare BCNs. The suspension of BCNs-loaded CoQ10 (CoQ10-BCNs) were prepared by antisolvent precipitation. The zeta potential of CoQ10-BCNs was about -36.01 mV. The properties of CoQ10, BCNs and CoQ10-BCNs were studied by scanning electron microscopy, transmission electron microscope, Fourier-transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry and thermo gravimetric analysis. The crystallinity of CoQ10 decreased in CoQ10-BCNs compared with the raw CoQ10, and CoQ10-BCNs have good physicochemical stability. In oral bioavailability studies, the area under curve (AUC) of CoQ10-BCNs was about 3.62 times higher than the raw CoQ10 in rats.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides, Bacterial / Water / Cellulose / Ubiquinone / Nanofibers Limits: Animals Language: En Journal: Carbohydr Polym Year: 2022 Document type: Article Country of publication: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polysaccharides, Bacterial / Water / Cellulose / Ubiquinone / Nanofibers Limits: Animals Language: En Journal: Carbohydr Polym Year: 2022 Document type: Article Country of publication: ENGLAND / ESCOCIA / GB / GREAT BRITAIN / INGLATERRA / REINO UNIDO / SCOTLAND / UK / UNITED KINGDOM