NF-&#954;B suppression synergizes with E7386, an inhibitor of CBP/ß-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.

Kanda, Yusuke; Ohata, Hirokazu; Miyazaki, Toshiaki; Sakai, Hiroaki; Mori, Yutaro; Shiokawa, Daisuke; Yokoi, Akira; Owa, Takashi; Ochiai, Atsushi; Okamoto, Koji

NF-κB suppression synergizes with E7386, an inhibitor of CBP/ß-catenin interaction, to block proliferation of patient-derived colon cancer spheroids.

Kanda, Yusuke; Ohata, Hirokazu; Miyazaki, Toshiaki; Sakai, Hiroaki; Mori, Yutaro; Shiokawa, Daisuke; Yokoi, Akira; Owa, Takashi; Ochiai, Atsushi; Okamoto, Koji.

Affiliation

Kanda Y; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Ohata H; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Miyazaki T; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Sakai H; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Mori Y; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Shiokawa D; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan.
Yokoi A; Eisai Co., Ltd., Tokyo, 112-8088, Japan.
Owa T; Eisai Co., Ltd., Tokyo, 112-8088, Japan.
Ochiai A; Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Tokyo, 104-0045, Japan.
Okamoto K; Division of Cancer Differentiation, National Cancer Center Research Institute, National Cancer Center, Tokyo, 104-0045, Japan. Electronic address: kojokamo@ncc.go.jp.

Biochem Biophys Res Commun ; 586: 93-99, 2022 01 01.

Article in En | MEDLINE | ID: mdl-34837838

Subject(s)

CREB-Binding Protein/genetics; NF-kappa B/genetics; Phenylenediamines/pharmacology; Pyrazines/pharmacology; Spheroids, Cellular/drug effects; Triazines/pharmacology; beta Catenin/genetics; Adenocarcinoma/drug therapy; Adenocarcinoma/genetics; Adenocarcinoma/metabolism; Adenocarcinoma/pathology; CREB-Binding Protein/metabolism; Cell Cycle Checkpoints/drug effects; Cell Cycle Checkpoints/genetics; Cell Proliferation/drug effects; Colonic Neoplasms/drug therapy; Colonic Neoplasms/genetics; Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms/drug therapy; Liver Neoplasms/genetics; Liver Neoplasms/metabolism; Liver Neoplasms/pathology; NF-kappa B/antagonists & inhibitors; NF-kappa B/metabolism; Primary Cell Culture; Spheroids, Cellular/metabolism; Spheroids, Cellular/pathology; Wnt Signaling Pathway; beta Catenin/metabolism

Key words

E7386; NF-κB; Patient-derived spheroids; WNT signaling Pathway

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenylenediamines / Pyrazines / Triazines / NF-kappa B / Spheroids, Cellular / CREB-Binding Protein / Beta Catenin Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2022 Document type: Article Affiliation country: Japan

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