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Chemical Structure, Hypoglycemic Activity, and Mechanism of Action of Selenium Polysaccharides.
Duan, Wen-Xia; Yang, Xiao-Hua; Zhang, Hua-Feng; Feng, Jing; Zhang, Meng-Yuan.
Affiliation
  • Duan WX; Provincial Research Station of Se-Enriched Foods in Hanyin County of Shaanxi Province, International Joint Research Center of Shaanxi Province for Food and Health Sciences, National Engineering Laboratory for Resources Development of Endangered Crude Drugs in Northwest China, Shaanxi Normal Universi
  • Yang XH; Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, People's Republic of China.
  • Zhang HF; Provincial Research Station of Se-Enriched Foods in Hanyin County of Shaanxi Province, International Joint Research Center of Shaanxi Province for Food and Health Sciences, National Engineering Laboratory for Resources Development of Endangered Crude Drugs in Northwest China, Shaanxi Normal Universi
  • Feng J; Municipal Expert Workstation for Hua-Feng Zhang, Academician and Expert Workstation in Pu'er City of Yunnan Province, Pu'er, 665600, People's Republic of China. isaacsau@sohu.com.
  • Zhang MY; Agrarian and Technological Institute, Peoples' Friendship University of Russia, Moscow, 119991, Russia.
Biol Trace Elem Res ; 200(10): 4404-4418, 2022 Oct.
Article in En | MEDLINE | ID: mdl-34843085
Selenium polysaccharides (Se-polysaccharides) are one of important forms of organic Se, in which selenium (Se) and polysaccharides are joined by covalent bonds. In the present review, recent progress in chemical structure and hypoglycemic activity of Se-polysaccharides is summarized. In particular, the mechanism underlying hypoglycemic capacity of Se-polysaccharides is discussed, and the relationship between hypoglycemic activity and chemical structure is analyzed. Besides, strategies for further research into chemical structure and hypoglycemic activity of Se-polysaccharides are proposed. Hypoglycemic activity of Se-polysaccharides is closely related to their inhibitory effect on α-amylase and α-glucosidase, influence on insulin signal pathway especially IRS-PI3K-Akt signaling pathway, and protection capacity against oxidative stress.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selenium Language: En Journal: Biol Trace Elem Res Year: 2022 Document type: Article Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selenium Language: En Journal: Biol Trace Elem Res Year: 2022 Document type: Article Country of publication: United States