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Porcine iPSC Generation: Testing Different Protocols to a Successful Application.
Iborra-Egea, Oriol; Martínez-Falguera, Daina; Roura, Santiago; Bayes-Genis, Antoni; Raya, Ángel; Gálvez-Montón, Carolina.
Affiliation
  • Iborra-Egea O; MyoCare Lab, ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), Badalona, Barcelona, Spain.
  • Martínez-Falguera D; MyoCare Lab, ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), Badalona, Barcelona, Spain.
  • Roura S; MyoCare Lab, ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), Badalona, Barcelona, Spain.
  • Bayes-Genis A; CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain.
  • Raya Á; MyoCare Lab, ICREC Research Program, Germans Trias i Pujol Health Research Institute (IGTP), Badalona, Barcelona, Spain.
  • Gálvez-Montón C; CIBER Cardiovascular, Instituto de Salud Carlos III, Madrid, Spain.
Methods Mol Biol ; 2454: 61-81, 2022.
Article in En | MEDLINE | ID: mdl-34845658
ABSTRACT
Stem cell therapy has an unparalleled potential to treat blood cancers, cardiovascular diseases and neurodegenerative conditions, among others. However, stem cell therapeutics must overcome multiple requirements before reaching clinical trials, including large animal safety and efficacy studies. In cardiovascular diseases swine models are the most widely adopted due to its great translational potential to humans. In this chapter, we will describe several protocols to induce iPSC dedifferentiation in swine fibroblasts, as well as conditioning treatments that may help in the reprogramming process.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Induced Pluripotent Stem Cells Type of study: Guideline Limits: Animals Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article Affiliation country: Spain
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cardiovascular Diseases / Induced Pluripotent Stem Cells Type of study: Guideline Limits: Animals Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2022 Document type: Article Affiliation country: Spain