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Perfect adaptation of CD8+ T cell responses to constant antigen input over a wide range of affinities is overcome by costimulation.
Trendel, Nicola; Kruger, Philipp; Gaglione, Stephanie; Nguyen, John; Pettmann, Johannes; Sontag, Eduardo D; Dushek, Omer.
Affiliation
  • Trendel N; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
  • Kruger P; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
  • Gaglione S; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
  • Nguyen J; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
  • Pettmann J; Sir William Dunn School of Pathology, University of Oxford, OX1 3RE Oxford, UK.
  • Sontag ED; Radcliffe Department of Medicine, Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, OX1 3RE Oxford, UK.
  • Dushek O; Electrical and Computer Engineering and Bioengineering, Northeastern University, Boston, MA 02115, USA.
Sci Signal ; 14(666): eaay9363, 2021 01 19.
Article in En | MEDLINE | ID: mdl-34855472
Reduced T cell responses by contrast antigen stimulation can be rescued by signals from costimulatory receptors.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / CD8-Positive T-Lymphocytes Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2021 Document type: Article Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Lymphocyte Activation / CD8-Positive T-Lymphocytes Language: En Journal: Sci Signal Journal subject: CIENCIA / FISIOLOGIA Year: 2021 Document type: Article Country of publication: United States