A proinflammatory diet is associated with an increased likelihood of first clinical diagnosis of central nervous system demyelination in women.
Mult Scler Relat Disord
; 57: 103428, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-34856497
ABSTRACT
BACKGROUND:
While a number of studies have examined associations between dietary factors and risk of multiple sclerosis (MS), little is known about intakes of inflammation-modulating foods and nutrients and risk of MS.OBJECTIVES:
To test associations between the Dietary Inflammatory Index (DII®) and risk of a first clinical diagnosis of central nervous system (CNS) demyelination (FCD) (267 cases, 507 controls) using data from the Ausimmune Study.METHODS:
The 2003-2006 Ausimmune Study was a multicentre, matched, case-control study examining environmental risk factors for an FCD, a common precursor to MS. The DII is a well-recognised tool that categorises individuals' diets on a continuum from maximally anti-inflammatory to maximally pro-inflammatory. The DII score was calculated from dietary intake data collected using a food frequency questionnaire. Conditional logistic regression models were used to estimate the association between DII and FCD separately for men and women.RESULTS:
In women, a higher DII score was associated with increased likelihood of FCD, with a 17% increase in likelihood of FCD per one-unit increase in DII score (adjusted odds ratio 1.17, 95% confidence interval 1.04-1.33). There was no association between DII and FCD in men (adjusted odds ratio 0.88, 95% confidence interval 0.73-1.07).CONCLUSIONS:
These findings suggest that a pro-inflammatory diet is associated with an increased likelihood of FCD in women.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diet
/
Multiple Sclerosis
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Mult Scler Relat Disord
Year:
2022
Document type:
Article
Affiliation country:
Australia