Diagnostic comparison between cord blood and filter paper for the screening of congenital hypothyroidism.
J Clin Lab Anal
; 36(1): e24149, 2022 Jan.
Article
in En
| MEDLINE
| ID: mdl-34859927
ABSTRACT
BACKGROUND:
Cord-blood and heel-prick TSH levels are essential in diagnosing and preventing the serious complications of congenital hypothyroidism, which mainly include intellectual disability. The study aimed to compare between cord-blood and heel-prick TSH sensitivity and specificity in detecting congenital hypothyroidism (CH) among newborn screened babies.METHOD:
The study included 21,012 newborn screened babies for congenital hypothyroidism starting from September 2013 until March 2019. Both cord-blood and heel-prick TSH were collected from each newborn. Heel prick and cord-blood TSH cutoff values of >21 µU/ml and >30 mIU/L respectively were considered positive.RESULTS:
Out of the total screened newborns, 12 were confirmed for having primary congenital hypothyroidism. Nine cases were positive for cord-blood TSH (Sensitivity 75%, specificity 99.9%, and a recall rate of 0.004%), while 139 cases were positive for heel-prick blood TSH (Sensitivity of 100%, specificity of 99.3%, and a recall rate of 0.60%).CONCLUSION:
For the screening of CH, heel prick is considered a superior method, but cord blood remains a practical option due to its cost-effectiveness, immediate action, and lower recall rate. Therefore, whenever recall is difficult and/or early discharge is the practice, cord blood is an alternative method to heel prick but not with cases of prematurity.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Specimen Collection
/
Neonatal Screening
/
Congenital Hypothyroidism
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Female
/
Humans
/
Male
/
Newborn
Language:
En
Journal:
J Clin Lab Anal
Journal subject:
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2022
Document type:
Article
Affiliation country:
Saudi Arabia