MIROs and DRP1 drive mitochondrial-derived vesicle biogenesis and promote quality control.

König, Tim; Nolte, Hendrik; Aaltonen, Mari J; Tatsuta, Takashi; Krols, Michiel; Stroh, Thomas; Langer, Thomas; McBride, Heidi M

König, Tim; Nolte, Hendrik; Aaltonen, Mari J; Tatsuta, Takashi; Krols, Michiel; Stroh, Thomas; Langer, Thomas; McBride, Heidi M.

Affiliation

König T; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Nolte H; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Aaltonen MJ; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Tatsuta T; Max Planck Institute for Biology of Ageing, Cologne, Germany.
Krols M; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Stroh T; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Langer T; Max Planck Institute for Biology of Ageing, Cologne, Germany.
McBride HM; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Nat Cell Biol ; 23(12): 1271-1286, 2021 12.

Article in En | MEDLINE | ID: mdl-34873283

Subject(s)

Cytoplasmic Vesicles/physiology; Dynamins/metabolism; Mitochondrial Dynamics/physiology; Mitochondrial Membranes/metabolism; Mitochondrial Proteins/metabolism; rho GTP-Binding Proteins/metabolism; Animals; COS Cells; Cell Line, Tumor; Chlorocebus aethiops; HEK293 Cells; HeLa Cells; Humans; Lipidomics; Membrane Proteins/metabolism; Mitochondria/metabolism; Mitochondrial Precursor Protein Import Complex Proteins/metabolism; Neurodegenerative Diseases/pathology; Peptide Elongation Factors/metabolism; Phosphatidic Acids/metabolism; Proteome/genetics; RNA Interference; RNA, Small Interfering/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Rho GTP-Binding Proteins / Cytoplasmic Vesicles / Mitochondrial Proteins / Dynamins / Mitochondrial Membranes / Mitochondrial Dynamics Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2021 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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