Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology.
Best Pract Res Clin Gastroenterol
; 54-55: 101756, 2021.
Article
in En
| MEDLINE
| ID: mdl-34874840
ABSTRACT
Immunosuppressive drugs have been key to the success of liver transplantation and are essential components of the treatment of inflammatory bowel disease (IBD) and autoimmune hepatitis (AIH). For many but not all immunosuppressants, therapeutic drug monitoring (TDM) is recommended to guide therapy. In this article, the rationale and evidence for TDM of tacrolimus, mycophenolic acid, the mammalian target of rapamycin inhibitors, and azathioprine in liver transplantation, IBD, and AIH is reviewed. New developments, including algorithm-based/computer-assisted immunosuppressant dosing, measurement of immunosuppressants in alternative matrices for whole blood, and pharmacodynamic monitoring of these agents is discussed. It is expected that these novel techniques will be incorporate into the standard TDM in the next few years.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmaceutical Preparations
/
Hepatitis, Autoimmune
/
Gastroenterology
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Best Pract Res Clin Gastroenterol
Journal subject:
GASTROENTEROLOGIA
Year:
2021
Document type:
Article