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Promoter-Driven Overexpression in Chromobacterium vaccinii Facilitates Access to FR900359 and Yields Novel Low Abundance Analogs.
Pistorius, Dominik; Buntin, Kathrin; Weber, Eric; Richard, Etienne; Bouquet, Caroline; Wollbrett, Séverine; Regenass, Hugo; Peón, Victor; Böhm, Marcel; Kessler, Régis; Gempeler, Thomas; Haberkorn, Anne; Wimmer, Laurin; Lanshoeft, Christian; Davis, John; Hainzl, Dominik; D'Alessio, Joseph Anthony; Manchado, Eusebio; Petersen, Frank.
Affiliation
  • Pistorius D; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Buntin K; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Weber E; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Richard E; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Bouquet C; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Wollbrett S; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Regenass H; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Peón V; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Böhm M; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Kessler R; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Gempeler T; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Haberkorn A; Oncology Disease Area, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Wimmer L; Chemical & Analytical Development, Technical Research & Development, Global Drug Development, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Lanshoeft C; Pharmakokinetic Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Davis J; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Hainzl D; Pharmacokinetic Sciences, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • D'Alessio JA; Oncology Disease Area, Novartis Institutes for BioMedical Research, Novartis Pharma AG, 250 Massachusetts Ave, Cambridge, MA, 02139, USA.
  • Manchado E; Oncology Disease Area, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
  • Petersen F; Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Novartis Campus, 4056, Basel, Switzerland.
Chemistry ; 28(8): e202103888, 2022 Feb 07.
Article in En | MEDLINE | ID: mdl-34878202
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromobacterium / Depsipeptides Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Switzerland Country of publication: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromobacterium / Depsipeptides Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: Switzerland Country of publication: Germany