Humoral protection to SARS-CoV2 declines faster in patients on TNF alpha blocking therapies.
RMD Open
; 7(3)2021 12.
Article
in En
| MEDLINE
| ID: mdl-34880128
ABSTRACT
BACKGROUND:
The persistence of the SARS-CoV2 pandemic, partly due to the appearance of highly infectious variants, has made booster vaccinations necessary for vulnerable groups. Questions remain as to which cohorts require SARS-CoV2 boosters. However, there is a critical lack of data on the dynamics of vaccine responses in patients with chronic inflammatory diseases (CID) undergoing immunosuppressive/disease modifying anti-rheumatic (DMARD) treatment. Here, we present the first data regarding the decline of the vaccine-induced humoral immune responses in patients with CID.METHODS:
23 patients with CID were monitored clinically and for anti-spike IgG and IgA levels, neutralization efficacy and antigen-specific CD4+ T cell responses over the first 6 months after SARS-CoV2 vaccination. 24 healthy individuals were included as controls.RESULTS:
While anti-spike IgG-levels declined in CID patients and healthy controls, patients receiving anti-TNF treatment showed significantly greater declines at 6 months post second vaccination in IgG and especially neutralizing antibodies. IgA levels were generally lower in CID patients, particularly during anti-TNF therapy. No differences in SARS-CoV2 spike-specific CD4+ T-cell frequencies were detected.CONCLUSION:
Although the long-term efficacy of SARS-CoV2 vaccination in CID patients undergoing disease-modifying therapy is still not known, the pronounced declines in humoral responses towards SARS-CoV2 6 months after mRNA vaccination in the context of TNF blockade should be considered when formulating booster regimens. These patients should be considered for early booster vaccinations.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunity, Humoral
/
Tumor Necrosis Factor Inhibitors
/
COVID-19 Vaccines
/
COVID-19
Limits:
Humans
Language:
En
Journal:
RMD Open
Year:
2021
Document type:
Article
Affiliation country:
Germany