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Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity.
Klein, Victoria G; Bond, Adam G; Craigon, Conner; Lokey, R Scott; Ciulli, Alessio.
Affiliation
  • Klein VG; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
  • Bond AG; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.
  • Craigon C; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.
  • Lokey RS; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, United States.
  • Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U.K.
J Med Chem ; 64(24): 18082-18101, 2021 12 23.
Article in En | MEDLINE | ID: mdl-34881891
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Esters / Amides Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Esters / Amides Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2021 Document type: Article Affiliation country: United States Country of publication: United States