Mutations in muscle-type creatine kinase impact HIV prevention.
Trends Pharmacol Sci
; 43(3): 165-167, 2022 03.
Article
in En
| MEDLINE
| ID: mdl-34887127
ABSTRACT
There is large interindividual variability in the efficacy of pre-exposure prophylaxis (PrEP) with tenofovir (TFV) in preventing HIV infection. Naturally occurring mutations in the creatine kinase M-type (CKM) gene examined by Mosher et al. could provide answers to why some individuals who have active serum creatine kinase in clinical assessments may not respond to TFV PrEP.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
/
Anti-HIV Agents
Limits:
Humans
Language:
En
Journal:
Trends Pharmacol Sci
Year:
2022
Document type:
Article
Affiliation country:
United States