Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases.

Murakami, Kazuma; Izuo, Naotaka; Bitan, Gal

Murakami, Kazuma; Izuo, Naotaka; Bitan, Gal.

Affiliation

Murakami K; Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. Electronic address: murakami.kazuma.4v@kyoto-u.ac.jp.
Izuo N; Laboratory of Pharmaceutical Therapy and Neuropharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
Bitan G; Department of Neurology, David Geffen School of Medicine, Brain Research Institute, and Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA. Electronic address: gbitan@mednet.ucla.edu.

J Biol Chem ; 298(1): 101478, 2022 01.

Article in En | MEDLINE | ID: mdl-34896392

Subject(s)

Amyloidogenic Proteins; Aptamers, Nucleotide; Neurodegenerative Diseases; Prion Diseases; Amyloidogenic Proteins/metabolism; Animals; Aptamers, Nucleotide/chemistry; Aptamers, Nucleotide/pharmacology; Aptamers, Nucleotide/therapeutic use; Central Nervous System/metabolism; Humans; Neurodegenerative Diseases/drug therapy; Neurodegenerative Diseases/metabolism; Prion Diseases/drug therapy; SELEX Aptamer Technique/methods

Key words

oligonucleotide, RNA, DNA, amyloid, Alzheimer's disease, Parkinson's disease, prion, blood-brain barrier, oligomer, exosome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prion Diseases / Neurodegenerative Diseases / Aptamers, Nucleotide / Amyloidogenic Proteins Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2022 Document type: Article Country of publication: United States

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