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Prenatal predictors of childhood anxiety disorders: An exploratory study of the role of attachment organization.
Galbally, Megan; Watson, Stuart J; van IJzendoorn, Marinus H; Tharner, Anne; Luijk, Maartje; de Kloet, E Ron; van Rossum, Elisabeth F C; Lewis, Andrew J.
Affiliation
  • Galbally M; Psychology, Murdoch University, Murdoch, Australia.
  • Watson SJ; School of Medicine, University of Notre Dame, Australia.
  • van IJzendoorn MH; King Edward Memorial Hospital, Subiaco, Perth, WA, Australia.
  • Tharner A; Psychology, Murdoch University, Murdoch, Australia.
  • Luijk M; School of Medicine, University of Notre Dame, Australia.
  • de Kloet ER; Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, The Netherlands.
  • van Rossum EFC; Department of Clinical, Educational and Health Psychology, Faculty of Brain Sciences, UCL, UK.
  • Lewis AJ; Department of Educational and Family Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Dev Psychopathol ; 35(3): 1296-1307, 2023 08.
Article in En | MEDLINE | ID: mdl-34911592
Childhood anxiety disorders (CAD) are a common childhood mental disorder and understanding early developmental pathways is key to prevention and early intervention. What is not understood is whether early life stress predictors of CAD might be both mediated by infant cortisol reactivity and moderated by infant attachment status. To address this question, this exploratory study draws on 190 women recruited in early pregnancy and followed together with their children until 4 years of age. Early life stress is operationalized as maternal depression measured using the Structured Clinical Interview for the DSM, Childhood Trauma Questionnaire, Parenting Stress Index, and antenatal maternal hair cortisol concentrations. Infant cortisol reactivity was measured at 12 months together with the Strange Situation Procedure and CAD assessed at 4 years of age using the Preschool Age Psychiatric Assessment. There was no direct association between attachment classification and CAD. Furthermore, infant cortisol reactivity neither mediated nor attachment moderated the association of early life stress predictors and CAD. However, only for infants with organized attachment classifications, higher maternal antenatal depression, and hair cortisol were associated with a higher risk of CAD.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydrocortisone / Depression Type of study: Prognostic_studies / Qualitative_research / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: En Journal: Dev Psychopathol Journal subject: PSICOLOGIA / PSIQUIATRIA Year: 2023 Document type: Article Affiliation country: Australia Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hydrocortisone / Depression Type of study: Prognostic_studies / Qualitative_research / Risk_factors_studies Limits: Child / Child, preschool / Female / Humans / Infant / Pregnancy Language: En Journal: Dev Psychopathol Journal subject: PSICOLOGIA / PSIQUIATRIA Year: 2023 Document type: Article Affiliation country: Australia Country of publication: United States