Importance of Utilizing Natural Isotopologue Transitions in Expanding the Linear Dynamic Range of LC-MS/MS Assay for Small-Molecule Pharmacokinetic Sample Analysis - A Mini-review.

Bach, Thanh; An, Guohua

Bach, Thanh; An, Guohua.

Affiliation

Bach T; Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, IA, USA.
An G; Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, IA, USA. Electronic address: guohua-an@uiowa.edu.

J Pharm Sci ; 111(5): 1245-1249, 2022 05.

Article in En | MEDLINE | ID: mdl-34919967

Subject(s)

Isotopes; Tandem Mass Spectrometry; Biological Assay; Chromatography, Liquid/methods; Humans; Tandem Mass Spectrometry/methods

Key words

Isotopologues; LCMS; Linear dynamic range; Natural isotopologue transitions; Small-molecule pharmacokinetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tandem Mass Spectrometry / Isotopes Limits: Humans Language: En Journal: J Pharm Sci Year: 2022 Document type: Article Affiliation country: United States Country of publication: United States

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