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Expedited synthesis of mannose-6-phosphate containing oligosaccharides.
Sletten, Eric T; Danglad-Flores, José; Leichnitz, Sabrina; Abragam Joseph, A; Seeberger, Peter H.
Affiliation
  • Sletten ET; Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
  • Danglad-Flores J; Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
  • Leichnitz S; Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany.
  • Abragam Joseph A; Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany.
  • Seeberger PH; Department of Biomolecular Systems, Max-Planck-Institute of Colloids and Interfaces, 14476, Potsdam, Germany; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195, Berlin, Germany. Electronic address: peter.seeberger@mpikg.mpg.de.
Carbohydr Res ; 511: 108489, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34922155
ABSTRACT
Currently, the reaction toolbox for the functionalization of glycans assembled on solid-phase is quite limited. Automated (1 h) and manual (overnight) phosphorylation protocols that enable the solid-phase synthesis of oligosaccharides containing up to two mannose-6-phosphates are presented. Automated glycan assembly expedited access to substrates and facilitated the screening of experimental conditions.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligosaccharides / Mannosephosphates Language: En Journal: Carbohydr Res Year: 2022 Document type: Article Affiliation country: Germany
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligosaccharides / Mannosephosphates Language: En Journal: Carbohydr Res Year: 2022 Document type: Article Affiliation country: Germany