Fragment-to-Lead Medicinal Chemistry Publications in 2020.
J Med Chem
; 65(1): 84-99, 2022 01 13.
Article
in En
| MEDLINE
| ID: mdl-34928151
ABSTRACT
Fragment-based drug discovery (FBDD) continues to evolve and make an impact in the pharmaceutical sciences. We summarize successful fragment-to-lead studies that were published in 2020. Having systematically analyzed annual scientific outputs since 2015, we discuss trends and best practices in terms of fragment libraries, target proteins, screening technologies, hit-optimization strategies, and the properties of hit fragments and the leads resulting from them. As well as the tabulated Fragment-to-Lead (F2L) programs, our 2020 literature review identifies several trends and innovations that promise to further increase the success of FBDD. These include developing structurally novel screening fragments, improving fragment-screening technologies, using new computer-aided design and virtual screening approaches, and combining FBDD with other innovative drug-discovery technologies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Publications
/
Drug Design
/
Chemistry, Pharmaceutical
/
Small Molecule Libraries
/
Drug Discovery
Type of study:
Guideline
Limits:
Animals
/
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2022
Document type:
Article
Affiliation country:
Netherlands