Repair time for oncogenic transformation in C3H/10T1/2 cells subjected to protracted X-irradiation.
Int J Radiat Biol Relat Stud Phys Chem Med
; 51(2): 219-26, 1987 Feb.
Article
in En
| MEDLINE
| ID: mdl-3493988
ABSTRACT
With exponential cultures of C3H/10T1/2 cells, we have investigated the effect of X-ray dose protraction on oncogenic cell transformation in the dose range 0.25-2 Gy. Within a particular experiment a constant exposure time was used. In different experiments exposure time varied between 1 and 5h. Cell transformation was analysed using the linear-quadratic relation, gamma (D) = alpha 1D + alpha 2D2, between transformation frequency per surviving cell and X-ray dose. Based on values of the linear coefficients, we developed an empirical formula for relating slopes of dose induction curves obtained at high or reduced dose rate condition. Our estimate of repair half-time for cell transformation with 95 per cent confidence limits is 2.4 (1.8, 3.0) h.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Transformation, Neoplastic
/
DNA Repair
Limits:
Animals
Language:
En
Journal:
Int J Radiat Biol Relat Stud Phys Chem Med
Year:
1987
Document type:
Article