KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?
Int J Mol Sci
; 22(24)2021 Dec 17.
Article
in En
| MEDLINE
| ID: mdl-34948344
ABSTRACT
In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activity. However, more recent evidence suggests that KLK3 may also have an opposite role, mediated by the ability of KLK3 to activate the (lymph)angiogenic vascular endothelial growth factors VEGF-C and VEGF-D, further discussed in the review.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatic Neoplasms
/
Kallikreins
/
Prostate-Specific Antigen
/
Neovascularization, Pathologic
Limits:
Humans
/
Male
Language:
En
Journal:
Int J Mol Sci
Year:
2021
Document type:
Article
Affiliation country:
Finland