7-Hydroxy questin, a new anthraquinone from a wetland fungus Aspergillus flavipes PJ03-11.
Nat Prod Res
; 36(21): 5484-5489, 2022 Nov.
Article
in En
| MEDLINE
| ID: mdl-34949143
ABSTRACT
One new anthraquinone, questinlin (1), four known anthraquinones (2-5), together with three known benzophenone derivatives (6-8) were isolated from a wetland fungus Aspergillus flavipes PJ03-11. Their structures were elucidated on the basis of detailed spectroscopic analysis, including 1D, 2D NMR (HMQC, HMBC), mass spectrometry, and optical rotation and IR spectra. In addition, the cytotoxic activities against three human cancer cell lines (HepG2, Caco-2 and A549) were evaluated. In this article, Aspergillus flavipes PJ03-11, a wetland soil fungus isolated from Honghaitan, Panjin city, Liaoning province, was used to study the secondary metabolites through one strain many compounds (OSMAC) methods. By changing the culture medium and adding the substance stimulating the metabolism of the strain into the fermentation medium, the peak type and amount of ethyl acetate extract in the fermentation medium were studied by HPLC. Finally, 2 mM MgCl2 was added into the rice solid medium for the expansion fermentation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anthraquinones
/
Wetlands
Limits:
Humans
Language:
En
Journal:
Nat Prod Res
Year:
2022
Document type:
Article
Affiliation country:
China