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Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease.
Ruganzu, John Bosco; Peng, Xiaoqian; He, Yingying; Wu, Xiangyuan; Zheng, Quzhao; Ding, Bo; Lin, Chengheng; Guo, Hongsong; Yang, Zikang; Zhang, Xiao; Yang, Weina.
Affiliation
  • Ruganzu JB; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Peng X; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • He Y; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Wu X; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Zheng Q; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Ding B; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Lin C; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Guo H; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Yang Z; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Zhang X; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China.
  • Yang W; Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, 710061, Shaanxi, China. Electronic address: wn_yang@mail.xjtu.edu.cn.
Mol Immunol ; 142: 22-36, 2022 02.
Article in En | MEDLINE | ID: mdl-34959070
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Amyloid beta-Protein Precursor / Toll-Like Receptor 4 / Alzheimer Disease / Neuroinflammatory Diseases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Immunol Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Glycoproteins / Receptors, Immunologic / Amyloid beta-Protein Precursor / Toll-Like Receptor 4 / Alzheimer Disease / Neuroinflammatory Diseases Type of study: Prognostic_studies Limits: Animals Language: En Journal: Mol Immunol Year: 2022 Document type: Article Affiliation country: China Country of publication: United kingdom