Improvement of mRNA Delivery Efficiency to a T Cell Line by Modulating PEG-Lipid Content and Phospholipid Components of Lipid Nanoparticles.

Tanaka, Hiroki; Miyama, Ryo; Sakurai, Yu; Tamagawa, Shinya; Nakai, Yuta; Tange, Kota; Yoshioka, Hiroki; Akita, Hidetaka

Tanaka, Hiroki; Miyama, Ryo; Sakurai, Yu; Tamagawa, Shinya; Nakai, Yuta; Tange, Kota; Yoshioka, Hiroki; Akita, Hidetaka.

Affiliation

Tanaka H; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-0856, Japan.
Miyama R; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-0856, Japan.
Sakurai Y; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-0856, Japan.
Tamagawa S; DDS Research Laboratory, NOF CORPORATION, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki City 210-0865, Japan.
Nakai Y; DDS Research Laboratory, NOF CORPORATION, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki City 210-0865, Japan.
Tange K; DDS Research Laboratory, NOF CORPORATION, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki City 210-0865, Japan.
Yoshioka H; DDS Research Laboratory, NOF CORPORATION, 3-3 Chidori-cho, Kawasaki-ku, Kawasaki City 210-0865, Japan.
Akita H; Laboratory of DDS Design and Drug Disposition, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City 260-0856, Japan.

Pharmaceutics ; 13(12)2021 Dec 06.

Article in En | MEDLINE | ID: mdl-34959378

Key words

T cells; lipid nanoparticles; mRNA delivery

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Full text: 1 Collection: 01-internacional Database: MEDLINE Aspects: Implementation_research Language: En Journal: Pharmaceutics Year: 2021 Document type: Article Affiliation country: Japan

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