CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.
Medicine (Baltimore)
; 100(47): e27874, 2021 Nov 24.
Article
in En
| MEDLINE
| ID: mdl-34964755
ABSTRACT
RATIONALE Monoclonal gammopathy of undetermined significance (MGUS) is a clinically asymptomatic clonal plasma cell or lymphoplasmacytic proliferative disorder. Recently, some case reports have described the association of pure red cell aplasia (PRCA) with MGUS, even with a relatively low monoclonal immunoglobulin burden. T large granular lymphocyte leukemia (T-LGLL) is a chronic lymphoproliferative disorder characterized by clonal expansion of T large granular lymphocytes, which is rare in China. There are some reports about T-LGL leukemia in patients with B-cell lymphoma; however, it is very rare that T-LGLL coexists with MGUS and clonal B-cell lymphoproliferative disorders (CB-LPD). PATIENT CONCERNS A 77-year-old man was hospitalized because of anemia. He was diagnosed with MGUS, CB-LPD, and PRCA. During the development of the disease, a group of abnormal T lymphocytes was detected by flow cytometry of peripheral blood. DIAGNOSIS Combining clinical manifestations with the result of T cell receptor gene rearrangement and immunophenotype, it was consistent with the diagnosis of T large granular lymphocyte leukemia. INTERVENTIONS:
The patient was treat with bortezomib and dexamethasone regimen, Rituximab and sirolimus.OUTCOMES:
The patient was transfusion independent after therapies. LESSONS We report a patient with 4 concomitant hematological disorders T-LGLL, MGUS, CB-LPD, and PRCA, aiming to represent the clinical and flow cytometry characteristics of these concomitant diseases, analyze the mechanism between diseases, and provide a clinical reference.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Monoclonal Gammopathy of Undetermined Significance
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Red-Cell Aplasia, Pure
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Leukemia, Large Granular Lymphocytic
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Lymphoproliferative Disorders
Type of study:
Etiology_studies
Limits:
Aged
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Humans
/
Male
Language:
En
Journal:
Medicine (Baltimore)
Year:
2021
Document type:
Article
Affiliation country:
China