Clinical application of protein-enhanced diet using mealworms in patients undergoing hepato-pancreato-biliary surgery.
Nutrition
; 94: 111538, 2022 02.
Article
in En
| MEDLINE
| ID: mdl-34965499
ABSTRACT
OBJECTIVE:
Patients with or without cancers who undergo major gastrointestinal surgery experience malnutrition owing to their catabolic status during the postoperative period. In this study, we evaluated the effect of the clinical application of protein-enhanced diet using mealworms in patients who underwent hepato-pancreato-biliary surgeries.METHODS:
This study was designed as a prospective, two-armed, and double-blinded phase III study. The target number of enrolled patients was 216, and the patients were randomized on a 11 basis, either to the trial group (consuming mealworms) or to the control group (consuming grain powder). The primary endpoint was to examine the changes in body composition, including phase angle. For secondary outcomes, the activities of immune cells were evaluated using the patients' blood samples.RESULTS:
No difference in the demographic characteristics of patients was observed. The ratio of the actual protein intake to the recommended daily intake in the trial group was significantly higher than that in the control group (110.03% vs. 98.80%, P = 0.023). In the data on body composition measured by InBody S-10 (Biospace, Seoul, South Korea), the ratios in body cell mass, fat free mass, muscle mass, and phase angle at the study endpoint compared with those at admission showed no statistically significant difference between the two groups. Immune cell analyses suggested that cytotoxic T cells in the trial group had higher activity than in the study group (1.192 vs. 0.974, P = 0.028).CONCLUSIONS:
In this study, protein-enhanced diet using mealworms clinically improved the activity of immune cells. However, it did not significantly improve the patients' nutritional status after they experienced hepato-pancreato-biliary surgeries.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Digestive System Surgical Procedures
/
Tenebrio
/
Malnutrition
Type of study:
Clinical_trials
/
Observational_studies
Aspects:
Determinantes_sociais_saude
Limits:
Animals
/
Humans
Language:
En
Journal:
Nutrition
Journal subject:
CIENCIAS DA NUTRICAO
Year:
2022
Document type:
Article
Affiliation country:
South Korea