Liver mesenchymal neoplasms: something old, something new.
Pathology
; 54(2): 225-235, 2022 Mar.
Article
in En
| MEDLINE
| ID: mdl-34965900
ABSTRACT
Histological examination of liver biopsies and resection specimens remains the gold standard to establish a definitive diagnosis of liver lesions. While hepatocellular carcinoma remains the most commonly encountered liver lesion on mass-directed biopsies, surgical pathologists must be aware of other entities that may pose diagnostic challenges, as an accurate diagnosis is key for patient management. Mesenchymal tumours of the liver are relatively uncommon, therefore many pathologists are unfamiliar with these tumours. While the clinical presentation and radiological features of these lesions often overlap, careful attention to histological clues can assist in weeding out various congeners to arrive at the most accurate diagnosis. An additional challenge when diagnosing mesenchymal tumours is the specimen type, as mass-directed core biopsies are limited and have become standard clinical practice. Besides careful attention to histological features, radiological findings and clinical history, immunohistochemical analysis and molecular studies have become of immense diagnostic value. In this review, we discuss several common and rare mesenchymal hepatic lesions as defined in the current World Health Organization (WHO) classification and most up-to-date literature. We also discuss immunohistochemistry panels and relevant molecular findings that may assist in rendering an accurate diagnosis when encountering these lesions in daily practice.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sarcoma
/
Angiomyolipoma
/
Neoplasms, Glandular and Epithelial
/
Hamartoma
/
Liver Neoplasms
/
Neoplasms, Muscle Tissue
/
Neoplasms, Vascular Tissue
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
Pathology
Year:
2022
Document type:
Article
Affiliation country:
United States