Electrostatic Perturbations in the Substrate-Binding Pocket of Taurine/&#945;-Ketoglutarate Dioxygenase Determine its Selectivity.

Ali, Hafiz Saqib; de Visser, Sam P

Electrostatic Perturbations in the Substrate-Binding Pocket of Taurine/α-Ketoglutarate Dioxygenase Determine its Selectivity.

Ali, Hafiz Saqib; de Visser, Sam P.

Affiliation

Ali HS; Manchester Institute of Biotechnology, The University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
de Visser SP; Department of Chemistry, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.

Chemistry ; 28(9): e202104167, 2022 Feb 16.

Article in En | MEDLINE | ID: mdl-34967481

Subject(s)

Dioxygenases; Ketoglutaric Acids; Dioxygenases/metabolism; Humans; Iron/chemistry; Ketoglutaric Acids/chemistry; Static Electricity; Taurine/chemistry; Taurine/metabolism

Key words

density functional theory; enzyme mechanism; hydrogen atom abstraction; inorganic reaction mechanisms; iron

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dioxygenases / Ketoglutaric Acids Limits: Humans Language: En Journal: Chemistry Journal subject: QUIMICA Year: 2022 Document type: Article Affiliation country: United kingdom Country of publication: Germany

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