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Serious acid-base disorder or life-threatening arrhythmia in patients with ABO-incompatible liver transplantation who received therapeutic plasma exchange - A report of two cases.
Lee, Sangho; Kim, Kyoung-Sun; Sang, Bo-Hyun; Hwang, Gyu-Sam.
Affiliation
  • Lee S; Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Kim KS; Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
  • Sang BH; Department of Anesthesiology and Pain Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
  • Hwang GS; Department of Anesthesiology and Pain Medicine, Laboratory for Cardiovascular Dynamics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Anesth Pain Med (Seoul) ; 17(1): 57-61, 2022 Jan.
Article in En | MEDLINE | ID: mdl-34974643
ABSTRACT

BACKGROUND:

Excessive citrate load during therapeutic plasma exchange (TPE) can cause metabolic alkalosis with compensatory hypercarbia and electrolyte disturbances. If TPE is required immediately before ABO-incompatible (ABOi) liver transplant (LT) surgery, metabolic derangement and severe electrolyte disturbance could worsen during LT anesthesia. CASE We report two ABOi LT cases who received TPE on the day of surgery because isoagglutinin titers did not be dropped below 18. One case had a surprisingly high metabolic alkalosis with a pH of 7.73 immediately after tracheal intubation because of hyperventilation during mask bagging. The other experienced sudden ventricular tachycardia and blood pressure drop after surgical incision accompanied with severe hypokalemia of 1.8 mmol/L despite supplementation with potassium.

CONCLUSIONS:

Special attention should be paid to patients who just completed TPE the operative day morning as they are vulnerable to severe acid-base disturbances and life-threatening ventricular arrhythmias in ABOi LT.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Anesth Pain Med (Seoul) Year: 2022 Document type: Article Publication country: COREA DEL SUR / CORÉIA DO SUL / KR / SOUTH KOREA

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Anesth Pain Med (Seoul) Year: 2022 Document type: Article Publication country: COREA DEL SUR / CORÉIA DO SUL / KR / SOUTH KOREA